Copper-Catalyzed Oxidative Ring Closure and Carboarylation of 2-Ethynylanilides

Á Sinai, Á Mészáros, T Gáti, V Kudar, A Palló…

Index: Sinai, Adam; Meszaros, Adam; Gati, Tamas; Kudar, Veronika; Pallo, Anna; Novak, Zoltan Organic Letters, 2013 , vol. 15, # 22 p. 5654 - 5657

Full Text: HTML

Citation Number: 24

Abstract

A new copper-catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts was developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond. The oxidative transformation includes an unusual 6-exo-dig cyclization step with the formation of C–O and C–C bonds.