1-Aminomethylbenzocycloalkanes: Conformationally Restricted Hallucinogenic Phenethylamine Analogues as Functionally Selective 5-HT2A Receptor Agonists 1

…, MR Braden, D Marona-Lewicka…

Index: Monte, Aaron P.; Marona-Lewicka, Danuta; Cozzi, Nicholas V.; Nelson, David L.; Nichols, David E. Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 651 - 663

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Citation Number: 59

Abstract

A series of conformationally restricted analogues of the hallucinogenic phenethylamine 1 (2, 5-dimethoxy-4-bromophenethylamine, 2C-B) was synthesized to test several hypotheses concerning the bioactive conformation of phenethylamine ligands upon binding to the 5-