Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent …

HH Lee, WR Wilson, DM Ferry, P van Zijl…

Index: Lee; Wilson; Ferry; Van Zijl; Pullen; Denny Journal of Medicinal Chemistry, 1996 , vol. 39, # 13 p. 2508 - 2517

Full Text: HTML

Citation Number: 47

Abstract

A series of nuclear-substituted derivatives of nitracrine N-oxide (2; a bis-bioreductive hypoxia-selective cytotoxin) were prepared and evaluated, seeking analogues of lower nitroacridine reduction potential. Disubstitution with Me or OMe groups at the 4-and 5- positions did not provide analogues with one-electron reduction potentials significantly lower than those of the corresponding monosubstituted derivatives (E (1) ca.-350 mV for ...