Skeletal diversity construction via a branching synthetic strategy

…, S Fergus, WRJD Galloway, A Bender, DJ Fox…

Index: Wyatt, Emma E.; Fergus, Suzanne; Galloway, Warren R. J. D.; Bender, Andreas; Fox, David J.; Plowright, Alleyn T.; Jessiman, Alan S.; Welch, Martin; Spring, David R. Chemical Communications, 2006 , # 31 p. 3296 - 3298

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Citation Number: 42

Abstract

Small molecule modulation of protein gene products (chemical genetics) is a powerful approach for the study of biological systems, 1 and is complementary to nucleic acid based approaches (such as siRNA) that target the gene locus or mRNA. In order to find a selective small molecule modulator of any protein function a structurally diverse compound collection is required. Natural products are structurally diverse; 2 however, there are many disadvantages with using ...