Tetrahedron

Synthesis of coumarins by Pt-catalyzed hydroarylation of propiolic acids with phenols

J Oyamada, T Kitamura

Index: Oyamada, Juzo; Kitamura, Tsugio Tetrahedron, 2006 , vol. 62, # 29 p. 6918 - 6925

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Citation Number: 64

Abstract

Synthesis of coumarins from phenols and propiolic acids was examined by using a Pt catalyst such as PtCl2/AgOTf, K2PtCl4/AgOTf, and K2PtCl4/AgOAc. Propiolic acid reacted even with less reactive phenols in trifluoroacetic acid to give coumarins and dihydrocoumarins. In the case of substituted propiolic acids, phenylpropiolic acid and 2- octynoic acid, the reactions proceeded selectively to afford coumarins in good to high ...