One-Pot Synthesis and Asymmetric Oxidation of 2-Nitro-4-(Trifluoromethyl) Benzene Containing Sulfides

…, SA Rubtsova, AV Kutchin, PA Slepukhin

Index: Rodygin, Konstantin S.; Rubtsova, Svetlana A.; Kutchin, Alexander V.; Slepukhin, Pavel A. Phosphorus, Sulfur and Silicon and the Related Elements, 2011 , vol. 186, # 9 p. 1885 - 1894

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Citation Number: 3

Abstract

Abstract An efficient one-pot method for the preparation of 2-nitro-4-(trifluoromethyl) benzene containing sulfides from 1, 1′-disulfanediylbis [2-nitro-4-(trifluoromethyl) benzene] is proposed. The corresponding enantiomerically enriched sulfoxides with up to 78% enantiomeric excess are prepared by the asymmetric oxidation of sulfides using a modified Sharpless method. The yield of sulfoxides is shown to decrease with an increase in the ...