Synthesis, anti–HIV, and antifungal activity of new benzensulfonamides bearing the 2, 5-disubstituted-1, 3, 4-oxadiazole moiety

M Zareef, R Iqbal, NA Al-Masoudi, JH Zaidi…

Index: Zareef, Muhammad; Iqbal, Rashid; Al-Masoudi, Najim A.; Zaidi, Javid H.; Arfan, Muhammad; Shahzad, Sohail A. Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 2 p. 281 - 298

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Citation Number: 28

Abstract

A series of novel chiral and achiral N-[1-(1, 3, 4-oxadiazol-2ylthio) alkyl]-4-methyl/chloro/ methoxybenzenesulfonamides 5a–l were prepared by the reaction of 4-(4-methyl, chloro, methoxyphenylsulfonamido) alkyl carboxylic acid hydrazides 4a–l with CS2 and KOH. Another series of new secondary benzenesulfonamides 10a–j and bis- benzenesulfonamides 11a–j have been synthesized by a new approach using Et3N and ...