Tetrahedron Letters

One-pot and catalyst-free synthesis of thiosemicarbazones via multicomponent coupling reactions

S Cunha, TL da Silva

Index: Cunha, Silvio; Silva, Tiago Lima da Tetrahedron Letters, 2009 , vol. 50, # 18 p. 2090 - 2093

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Citation Number: 22

Abstract

A novel and efficient procedure for the synthesis of thiosemicarbazones has been achieved via a multicomponent and catalyst-free reaction of phenyl or p-chlorophenyl isothiocyanate, hydrazine, and aldehydes or ketones. The method afforded 20 thiosemicarbazones in good yields and short reaction time.