Versatile. beta.-ketoester and. beta.-ketonitrile synthesis through sulfide contraction

K Shiosaki, G Fels, H Rapoport

Index: Shiosaki, Kazumi; Fels, Gregor; Rapoport, Henry Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3230 - 3234

Full Text: HTML

Citation Number: 43

Abstract

" Yield for method A refers to two-step process from acid chloride to thioamide; method B is for one-step transformation from amide to thioamide. Mp 73-75" C. Bp 100" C (150 pm). Bp 90" C (150 pm). e Bp 100" C (100 pm). amenable to this process were investigated as well as the conditions required to efficiently invoke the extrusion. This led to the development of a reagent which served the dual role of base to abstract the a-proton and thiophile to assist ...