An all-cis-functionalized cyclopropane template to connect the three peptide chains in a collagen model is designed. Stereoselective synthesis of cyclopropane-assembled collagen- model 2b with the minimum unit of Gly-Pro-Pro is based on a novel 1-seleno-2-silylethene [2+ 1] cycloaddition strategy. Reaction of the 1-seleno-2-silylethene 4 with triester- substituted olefin 5 in the presence of ZnI 2 gives [2+ 1] cycloadduct 6 stereoselectively. ...
