Synlett

N-Formylsaccharin: A New Formylating Agent

T Cochet, V Bellosta, A Greiner, D Roche, J Cossy

Index: Cochet, Thomas; Bellosta, Veronique; Greiner, Alfred; Roche, Didier; Cossy, Janine Synlett, 2011 , # 13 p. 1920 - 1922

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Citation Number: 8

Abstract

When primary amines 2 (1 equiv) were treated with 1 (1 equiv) in THF for 15 minutes at room temperature, the N-formamides 3 were isolated in excellent yield after a saturated aqueous NaHCO 3 workup. No purification was required during isolation of 3 due to the acidic nature of saccharin (pK a = 1.5) and to the high solubility of its sodium salt in water. [²9] The results are reported in Table [¹] . Primary N-alkylamines 2a-e were transformed to the corresponding ...