The synthesis of a series of RGD mimetics is described. All compounds have a 1, 4: 3, 6- dianhydrohexitol core, a variable linker to a guanidino group, and a serine ether to mimic the carboxylic acid. Two types of linkers were combined with 1, 4: 3, 6-dianhydro-D-sorbitol (1– 4) and with 1, 4: 3, 6-dianhydro-L-iditol (5). The five compounds were tested as potential integrin antagonists in a receptor binding assay (αIIbβ3, αvβ3, and αvβ5 type). Receptor ...
