Application of a Flexible Synthesis of (5 R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase

JM McFadden, SM Medghalchi…

Index: Kunieda, Takehisa; Nagamatsu, Tomohisa; Higuchi, Tsunehiko; Hirobe, Masaaki Tetrahedron Letters, 1988 , vol. 29, # 18 p. 2203 - 2206

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Citation Number: 76

Abstract

... Volume: Page: ... Finally, a third subclass (16b, 29, 30) is also active against FAS (IC 50 = ≤20 μg/mL), is cytotoxic to cancer cells (IC 50 ... Acid hydrolysis of 17k−l provided acids 18a (98%) and 18b (89%, Scheme 8). Coupling reactions of 18 with EDC, or tris(2,3 ...