Antineoplastic Agents. 445. Synthesis and evaluation of structural modifications of (Z)-and (E)-Combretastatin A-4 1

…, E Hamel, JM Schmidt, RK Pettit

Index: Pettit, George R.; Grealish, Matthew P.; Jung, M. Katherine; Hamel, Ernest; Pettit, Robin K.; Chapuis, J.-Charles; Schmidt, Jean M. Journal of Medicinal Chemistry, 2002 , vol. 45, # 12 p. 2534 - 2542

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Citation Number: 114

Abstract

A series of cis-and trans-stilbenes related to combretastatin A-4 (1a), with a variety of substituents at the 3'-position of the aryl B-ring, were synthesized and evaluated for inhibitory activity employing six human cancer cell lines (NCI-H460 lung carcinoma, BXPC-3 pancreas, SK-N-SH neuroblastoma, SW1736 thyroid, DU-145 prostate, and FADU pharynx- squamous sarcoma) as well as the P-388 murine lymphocyte leukemia cell line. Several ...