e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Chemistry Letters
Zinc (0)-copper (I) chloride promoted reaction of methyl dichlorofluoroacetate with carbonyl compounds. A new efficient method for the synthesis of methyl (Z)-. ALPHA …
Methyl dichlorofluoroacetate, easily prepared from methyl trichloroacetate and antimony (III) fluoride, underwent the reductive coupling–elimination reaction with carbonyl compounds in the presence of zinc (0), a catalytic amount of copper (I) chloride, acetic anhydride, and molecular sieves to give the corresponding (Z)-α-fluoro-α, β-unsaturated carboxylic acid methyl esters in high yields.
