Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl] acrylic acid amides and their antimalarial activity

…, J Wiesner, K Silber, P Haebel, R Ortmann…

Index: Wiesner; Mitsch; Altenkaemper; Ortmann; Jomaa; Schlitzer, Martin Pharmazie, 2003 , vol. 58, # 12 p. 854 - 856

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Citation Number: 25

Abstract

Water solubility was previously found to be essential for in vivo-antimalarial activity of a novel type of benzophenone-based farnesyltransferase inhibitors. Introduction of a α-amino group into the phenylacetic acid substructure provided more soluble compounds with high

Synthesis of Functionalized 2-Arylthiophenes with Triarylbis...

[Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J. Synlett, 2011 , # 9 p. 1324 - 1330]

Synthesis and structure–activity relationships of 5-phenylth...

[Noguchi, Toshiya; Hasegawa, Masahiro; Tomisawa, Kazuyuki; Mitsukuchi, Morihiro Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 22 p. 4729 - 4742]