Design, Synthesis, and Examination of Neuron Protective Properties of Alkenylated and Amidated Dehydro-Silybin Derivatives†

…, JX Gong, F Wang, YB Feng, QF Tao…

Index: Yang, Lei Xiang; Huang, Ke Xin; Li, Hai Bo; Gong, Jing Xu; Wang, Feng; Feng, Yu Bing; Tao, Qiao Feng; Wu, Yi Hang; Li, Xiao Kun; Wu, Xiu Mei; Zeng, Su; Spencer, Shawn; Zhao, Yu; Qu, Jia Journal of Medicinal Chemistry, 2009 , vol. 52, # 23 p. 7732 - 7752

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Citation Number: 23

Abstract

A series of C7-O-and C20-O-amidated 2, 3-dehydrosilybin (DHS) derivatives ((±)-1a− f and (±)-2), as well as a set of alkenylated DHS analogues ((±)-4a− f), were designed and de novo synthesized. A diesteric derivative of DHS ((±)-3) and two C23 esterified DHS analogues ((±)-5a and (±)-5b) were also prepared for comparison. The cell viability of PC12 cells, Fe2+ chelation, lipid peroxidation (LPO), free radical scavenging, and xanthine ...