Tetrahedron

Studies on a three-step preparation of β-fluoroalkyl acrylates from fluoroacetic esters

M Jagodzinska, F Huguenot, M Zanda

Index: Jagodzinska, Monika; Huguenot, Florent; Zanda, Matteo Tetrahedron, 2007 , vol. 63, # 9 p. 2042 - 2046

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Citation Number: 23

Abstract

β-Fluoroalkyl-acrylic esters are valuable building blocks for the synthesis of organofluorine compounds. Although the preparation of several β-fluoroalkyl-acrylates is known, a general and straightforward lab-scale methodology for the preparation of multigram amounts of these compounds from fluoroacetic esters is not available, and the related chemistry has not been investigated in detail. We now describe an optimized three-step protocol relying on:( ...