Tetrahedron Letters

Oxidation of 1-benzyldihydroisoquinolines or 1-benzyltetrahydroisoquinolines with dioxygen to 1-benzoylisoquinolines

H Gan, Y Lu, Y Huang, L Ni, J Xu, H Yao, X Wu

Index: Gan, Haifeng; Lu, Yunyu; Huang, Yue; Ni, Lijun; Xu, Jinyi; Yao, Hequan; Wu, Xiaoming Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1320 - 1324

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Citation Number: 6

Abstract

An environmental-benign methodology to synthesize 1-benzoylisoquinolines from 1-benzyl- 3, 4-dihydroisoquinolines or 1-benzyl-1, 2, 3, 4-tetrahydroisoquinolines using dioxygen as an oxidant was developed. This methodology in combination with Bischler-Napieralski reaction leads to a facile synthesis of 1-benzoylisoquinolines from phenylacetic acids and phenylethanamines.