Synthesis of non-natural flavanones and dihydrochalcones in metabolically engineered yeast

SR Werner, H Chen, H Jiang, JA Morgan

Index: Werner, Sean R.; Chen, Hao; Jiang, Hanxiao; Morgan, John A. Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 66, # 3-4 p. 257 - 263

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Citation Number: 6

Abstract

Flavonoids are plant phenolic compounds that have many interesting medicinal properties. Therefore, there is interest in the synthesis of non-natural flavonoids as they may possess new or enhanced biological activities. In this study, metabolically engineered Saccharomyces cerevisiae expressing 4-coumaroyl: CoA-ligase (4CL) and chalcone synthase (CHS) was explored as a platform for producing non-natural flavanones and ...