Biosynthesis of aspyrone, a metabolite of Aspergillus melleus: advanced precursor studies to identify the product of the polyketide synthase

J Staunton, AC Sutkowski

Index: Staunton, J.; Sutkowski, Andrew C. Journal of the Chemical Society, Chemical Communications, 1991 , # 16 p. 1108 - 1110

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Citation Number: 15

Abstract

Incorporation studies with deuterium-labelled compounds, using 2H NMR spectroscopy as method of analysis, have shown that a C10 acid,(4E, 6E, 8E)-3-hydroxydeca-4, 6, 8-trienoic acid, is incorporated intact into aspyrone when administered to growing cells of Aspergillus melleus.