… and evaluation of duocarmycin SA analogs incorporating the methyl 1, 2, 8, 8a-tetrahydrocyclopropa [c] oxazolo [2, 3-e] indol-4-one-6-carboxylate (COI) alkylation …

KE Boyle, KS MacMillan, DA Ellis, JP Lajiness…

Index: Boyle, Kristopher E.; MacMillan, Karen S.; Ellis, David A.; Lajiness, James P.; Robertson, William M.; Boger, Dale L. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 6 p. 1854 - 1857

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Citation Number: 7

Abstract

The design, synthesis and evaluation of methyl 1, 2, 8, 8a-tetrahydrocyclopropa [c] oxazolo [2, 3-e] indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit.