Tetrahedron

Enzymatic kinetic resolution of racemic cyanohydrins via enantioselective acylation

Q Xu, Y Xie, X Geng, P Chen

Index: Xu, Qing; Xie, Yongli; Geng, Xiaohong; Chen, Peiran Tetrahedron, 2010 , vol. 66, # 3 p. 624 - 630

Full Text: HTML

Citation Number: 21

Abstract

Enzymatic kinetic resolution of a series of aromatic and aliphatic cyanohydrins in organic media has been investigated. The behavior of potential lipases, molecular sieves, acyl reagent, reaction temperature, and organic solvents on the kinetic resolution was studied. The influence of substrate structure, steric, and electronic nature and position of the aryl substituent on the enantioselectivity was discussed. Under the optimized reaction ...