Tetrahedron: Asymmetry

A study of asymmetric hydrocyanation of heteroaryl carboxaldehydes catalyzed by (R)-oxynitrilase under micro-aqueous conditions

P Chen, S Han, G Lin, H Huang, Z Li

Index: Chen, Peiran; Han, Shiqing; Lin, Guoqiang; Huang, Hao; Li, Zuyi Tetrahedron Asymmetry, 2001 , vol. 12, # 23 p. 3273 - 3279

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Citation Number: 25

Abstract

A number of new optically active heteroaryl cyanohydrins have been prepared by hydrocyanation under micro-aqueous conditions catalyzed by almond meal (containing (R)- oxynitrilase). Substituent effects on the reaction are discussed. This micro-aqueous method provides an efficient, convenient and economical approach to optically active cyanohydrins.