Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged …

…, H Fu, AT Papoulis, SF Queener

Index: Rosowsky, Andre; Papoulis, Andrew T.; Queener, Sherry F. Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 913 - 918

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Citation Number: 64

Abstract

As part of a larger search for potent as well as selective inhibitors of dihydrofolate reductase (DHFR) enzymes from opportunistic pathogens found in patients with AIDS and other immune disorders, N-[(2, 4-diaminopteridin-6-yl) methyl] dibenz [b, f] azepine (4a) and the corresponding dihydrodibenz [b, f] azepine, dihydroacridine, phenoxazine, phenothiazine, carbazole, and diphenylamine analogues were synthesized from 2, 4-diamino-6-( ...