Chemical communications

Phosphazene base-catalyzed condensation of trimethylsilylacetate with carbonyl compounds

K Kobayashi, M Ueno, Y Kondo

Index: Kobayashi, Koji; Ueno, Masahiro; Kondo, Yoshinori Chemical Communications, 2006 , # 29 p. 3128 - 3130

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Abstract

Phosphazene bases 2 developed by Schwesinger and proazaphosphatranes 3 developed by Verkade are known as strong non-metallic organic superbases (Fig. 1). Among them, t-Bu-P4 base shows extremely high basicity and has been used for various selective deprotonative transformations. 4 The strong affinity of t-Bu-P4 base to protons is regarded as synthetically useful, however the ability of t-Bu-P4 base to activate α-silylalkyl compounds has not ...