Abstract The (3′→ 2′)-phosphodiester glyceric acid backbone containing an acyclic oligomer tagged with 2, 4-disubstituted pyrimidines as alternative recognition elements have been synthesized. Strong cross-pairing of a 2, 4-dioxo-5-aminopyrimidine hexamer, rivaling locked nucleic acid (LNA) and peptide nucleic acid (PNA), with complementary adenine- containing DNA and RNA sequences was observed. The corresponding 2, 4-diamino-and ...
