e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron Letters
Solvolysis of 1-aryl-1-(trifloromethyl) ethyl tosylates. Evidence for an extremely high electron demand carbenium ion intermediate due to the presence of α- …
Abstract The rate-retarding effect of?-trifluoromethyl group observed in the solvolysis of 1- aryl-1-(trifluoromethyl) ethyl tosylates is so profound that a very large negative α+ value,− 8.82, is resulted and the 1-phenyl derivative becomes even less reactive than benzyl
