Selective acylation of a sterically hindered hydroxyl group of unsymmetrical diols containing a primary hydroxyl group such as 1, 5??hexanediol in the presence of silica …

…, Y Ide, R Honda, T Chihara

Index: Ogawa, Haruo; Ide, Yuko; Honda, Ryoichi; Chihara, Teiji Journal of Physical Organic Chemistry, 2003 , vol. 16, # 6 p. 355 - 358

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Citation Number: 7

Abstract

Abstract The more hindered monoacetates were selectively formed in the presence of silica gel with acetyl chloride by refluxing a suspension of unsymmetrical diols containing a primary hydroxyl group such as 1, 5-hexanediol preadsorbed on silica gel. Such regioselectivity was observed through preferential adsorption via a primary hydroxyl group of the diols. Copyright© 2003 John Wiley & Sons, Ltd.