Synthesis and biological evaluation of an N10-Psec substituted pyrrolo [2, 1-c][1, 4] benzodiazepine prodrug

…, PW Howard, LR Kelland, DE Thurston

Index: Berry, Jane M.; Howard, Philip W.; Kelland, Lloyd R.; Thurston, David E. Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 10 p. 1413 - 1416

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Citation Number: 7

Abstract

The first example of an N10-protected (eg, Psec, 15) pyrrolo [2, 1-c][1, 4] benzodiazepine (PBD) analogue that retains significant cytotoxicity in a number of tumour cell lines is reported. This prototype could lead to a new generation of clinically useful N10-protected PBD prodrugs.