Bioorganic & medicinal chemistry letters

Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps

S Löber, H Hübner, P Gmeiner

Index: Loeber, Stefan; Huebner, Harald; Gmeiner, Peter Bioorganic & Medicinal Chemistry Letters, 1999 , vol. 9, # 1 p. 97 - 102

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Citation Number: 84

Abstract

Piperazinylmethyl substituted pyrazolo [1, 5-a] pyridines and related heterocycles were synthesized and found to recognize selectively the dopamine D4 receptor. For the most potent derivative 10d a Ki value of 2.0 nM was observed. SAR studies including the comparison of molecular isopotential surfaces were performed.