Phosphonic Systems. 7. Reactions of 2, 3-Epoxyphosphonates with Nucleophiles: Preparation of 2, 3-Disubstituted Alkylphosphonic Esters and Related Systems

…, MJ Mphahlele, AM Modro, TA Modro…

Index: Phillips, A. M. M. M.; Mphahlele, M. J.; Modro, A. M.; Modro, T. A.; Zwierzak, A. Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 71, p. 165 - 174

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Citation Number: 8

Abstract

Abstract Diethyl 2, 3-epoxyalkylphosphonates react regioselectively with various nucleophilic reagents yielding 2-hydroxy-3-substituted alkylphosphonic esters. The 2- hydroxy functionality can be easily converted into an ester or ether derivative. The reaction of diethyl 2, 3-epoxypropylphosphonate with ketone enamines does not lead to hydroxyketophosphonates, but results in the incorporation of the 3-phosphonopropylidene ...