1, 4–Diarylpiperazines and analogs as anti-tubercular agents: Synthesis and biological evaluation

…, D Cappoen, J Laurent, D Stanicki, A Mayence…

Index: Forge; Cappoen; Laurent; Stanicki; Mayence; Huang; Verschaeve; Huygen; Vanden Eynde European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 95 - 101

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Citation Number: 15

Abstract

Despite progress in modern chemotherapy to combat tuberculosis, the causative pathogen Mycobacterium tuberculosis (M. tb.) is far from eradicated. Bacillary resistance to anti- mycobacterial agents, bacillary persistence and human immunodeficiency virus (HIV) co- infection hamper current drug treatment to completely cure the infection, generating a constant demand for novel drug candidates to tackle these problems. A small library of ...

Synthesis and pharmacological evaluation of new arylpiperazi...

[Khatri, Manisha; Rai, Santosh Kumar; Alam, Sameena; Vij, Anjana; Tiwari, Manisha Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 5 p. 1890 - 1897]

Benzodiazepines as potent and selective bradykinin B1 antago...

[Wood, Michael R.; Kim, June J.; Han, Wei; Dorsey, Bruce D.; Homnick, Carl F.; DiPardo, Robert M.; Kuduk, Scott D.; MacNeil, Tanya; Murphy, Kathy L.; Lis, Edward V.; Ransom, Richard W.; Stump, Gary L.; Lynch, Joseph J.; O'Malley, Stacey S.; Miller, Patricia J.; Chen, Tsing-Bau; Harrell, Charles M.; Chang, Raymond S. L.; Sandhu, Punam; Ellis, Joan D.; Bondiskey, Peter J.; Pettibone, Douglas J.; Freidinger, Roger M.; Bock, Mark G. Journal of Medicinal Chemistry, 2003 , vol. 46, # 10 p. 1803 - 1806]