A mild and efficient synthesis of 4-quinolones and quinolone heterocycles

D Zewge, C Chen, C Deer, PG Dormer…

Index: Zewge, Daniel; Chen, Cheng-Yi; Deer, Curtis; Dormer, Peter G.; Hughes, Dave L. Journal of Organic Chemistry, 2007 , vol. 72, # 11 p. 4276 - 4279

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Citation Number: 79

Abstract

The cycloacylation of aniline derivatives to 4-quinolones in the presence of Eaton's reagent is described. This high-yielding methodology is applicable to a wide variety of functionalized anilines and requires milder conditions than those traditionally employed. This cyclization protocol is used to prepare a host of heterocycles and bis-quinolones and is characterized by relatively low reaction temperature and ease of product isolation.