Studies on new phosphodiesterase inhibitors. I. Synthesis of 1-(2, 3-epoxypropoxy)-2 (4)-fluorobenzenes and 1-(2-hydroxy-3-morpholinopropoxy and piperazino) …

NR BAKER, NG BYRNE, AP ECONOMIDES…

Index: Baker; Byrne; Economides; Javed Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 6 p. 1045 - 1048

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Citation Number: 15

Abstract

A series of 1-(2, 3-epoxypropoxy)-2 (4)-fluorobenzenes and their corresponding 1-(2- hydroxy-3-morpholino propoxy and piperazino) fluorobenzene derivatives (8a-f) were synthesised via a short synthetic route in good chemical yields and were evaluated for intropic and chronotropic activity in isolated guinea-pig atria preparation. The compounds act as potential phosphodiesterase (PDE) inhibitors with desirable biological activity and ...