Amine Activation: Synthesis of N-(Hetero) arylamides from Isothioureas and Carboxylic Acids

YP Zhu, S Sergeyev, P Franck, RVA Orru…

Index: Schaefer, Gabriel; Bode, Jeffrey W. Organic Letters, 2014 , vol. 16, # 5 p. 1526 - 1529

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Abstract

... Organic Letters. Advanced Search. ... The synthesis of the amide functional group is paramount in organic chemistry ... When N-tert-butyl-S,N′-diphenylisothiourea (1d) was used instead of 1a, full conversion could be achieved with only 2.5 mol % catalyst, and the desired product 4a ...