MedChemComm

2-[18 F] Fluoroethyl tosylate–a versatile tool for building 18 F-based radiotracers for positron emission tomography

T Kniess, M Laube, P Brust, J Steinbach

Index: Bauman; Piel; Hoehnemann; Krauss; Jansen; Solbach; Dannhardt; Roesch Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 10 p. 645 - 656

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Citation Number: 1

Abstract

... properties like ethyl and methyl groups and is expected to maintain the pharmacological properties of a lead compound. ... Rösch et al. ... synthesized 18 F-labeled compounds derived from FAUC346 with the methoxy functionality being replaced with a fluoroethoxy bioisostere (Fig. ...

 Related Synthetic Route
Benzyl chloride Structure

100-44-7

Benzyl chloride

3-Aminophenol Structure

591-27-5

3-Aminophenol

~35%

3-Benzyloxyaniline Structure

1484-26-0

3-Benzyloxyaniline

Ethyl 4,6-dichloro-1H-indole-2-carboxylate Structure

53995-82-7

Ethyl 4,6-dichl...

N-Methylformanilide Structure

93-61-8

N-Methylformanilide

~75%

Ethyl 4,6-dichloro-3-formyl-1H-indole-2-carboxylate Structure

153435-96-2

Ethyl 4,6-dichl...

4-Nitrophenol Structure

100-02-7

4-Nitrophenol

~%

4-(2-fluoroethoxy)aniline Structure

1547-12-2

4-(2-fluoroetho...

1-(2-fluoroethoxy)-2-nitrobenzene Structure

132838-18-7

1-(2-fluoroetho...

~%

2-(2-FLUORO-ETHOXY)-PHENYLAMINE Structure

1547-11-1

2-(2-FLUORO-ETH...

o-Nitrophenol Structure

88-75-5

o-Nitrophenol

~%

2-(2-FLUORO-ETHOXY)-PHENYLAMINE Structure

1547-11-1

2-(2-FLUORO-ETH...

N/A Structure

1335465-57-0

N/A

~%

3-chloro-4-(2-fluoroethoxy)aniline Structure

65617-96-1

3-chloro-4-(2-f...

2-Chloro-4-nitrophenol Structure

619-08-9

2-Chloro-4-nitr...

~%

3-chloro-4-(2-fluoroethoxy)aniline Structure

65617-96-1

3-chloro-4-(2-f...

Benzyl chloride Structure

100-44-7

Benzyl chloride

aminophenol Structure

95-55-6

aminophenol

~53%

2-(Benzyloxy)aniline Structure

20012-63-9

2-(Benzyloxy)aniline

1-Bromo-2-fluoroethane Structure

762-49-2

1-Bromo-2-fluor...

o-Nitrophenol Structure

88-75-5

o-Nitrophenol

~51%

1-(2-fluoroethoxy)-2-nitrobenzene Structure

132838-18-7

1-(2-fluoroetho...


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