Tetrahedron

Synthesis of nitrogen bicyclic scaffolds: pyrimido [1, 2-a] pyrimidine-2, 6-diones

S Grosjean, S Triki, JC Meslin, K Julienne, D Deniaud

Index: Grosjean, Sylvain; Triki, Smail; Meslin, Jean-Claude; Julienne, Karine; Deniaud, David Tetrahedron, 2010 , vol. 66, # 52 p. 9912 - 9924

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Citation Number: 15

Abstract

The multi-step synthesis of 1, 3, 7-trisubstituted pyrimido [1, 2-a] pyrimidinediones starting from isothiocyanates is described. These nitrogen bicycles were prepared by an iterative sequence of functionalization/cyclocondensation reactions.[4+ 2] Cycloaddition reactions took place between diazadienic chains and various acyl chlorides providing sophisticated heterobicycles.