Evaluation of Novel Synthetic Methods for the Preparation of the Sodium Channel Inhibitor, GW273225X

…, HF Clark, S Clark, NP Henley, RAJ Horan…

Index: Walker, Matthew D.; Albinson, F. David; Clark, Hugh F.; Clark, Stacy; Henley, Nicholas P.; J. Horan, Richard A.; Jones, Chris W.; Wade, Charles E.; Ward, Richard A. Organic Process Research and Development, 2014 , vol. 18, # 1 p. 82 - 88

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Abstract

The evaluation of efficient synthetic methods for the preparation of (R)-2, 4-diamino-5-(2, 3- dichlorophenyl)-6-fluoromethylpyrimidine, GW273225X (1), is described. The initial synthesis using ethylfluoroacetate was evaluated against three alternative routes using ...