Syntheses of isotopically labelled L-α-amino acids with an asymmetric centre at C-3

…, RA Hughes, NM Kelly, A Sutherland…

Index: Harding, John R.; Hughes, Rachael A.; Kelly, Nicholas M.; Sutherland, Andrew; Willis, Christine L. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 20 p. 3406 - 3416

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Citation Number: 19

Abstract

Approaches are described to the synthesis of a series of isotopically labelled L-α-amino acids each with an asymmetric centre at C-3, including isoleucine, allo-isoleucine, threonine and allo-threonine. The methods may be simply adapted for the selective incorporation of an isotopic label at each site of L-valine including the selective labelling of either diastereotopic methyl group with carbon-13 and/or deuterium and labelling of the amine with nitrogen-15.