An efficient enantioselective total synthesis of antitumor lignans: synthesis of enantiomerically pure 4-hydroxyalkanenitriles via an enzymic reaction

…, J Chika, Y Takagi, S Nishiyama

Index: Itoh; Chika; Takagi; Nishiyama Journal of Organic Chemistry, 1993 , vol. 58, # 21 p. 5717 - 5723

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Citation Number: 56

Abstract

Natural antitumor lignans have been recognized as challenging targets for organic synthesis. l The skeleton of 2, 3-disubstituted-4-butanolide 2 is the most important feature found in 1ignans. l Optically active 4-butanolide 3 has frequently been used for the asymmetric synthesis of lignans as the key starting intermediate.'* Although