Abstract A cyclic tetrapeptide with inhibitory activity toward cell adhesion, cyclo (-Arg-Gly- Asp-Phg-)(phg, phenylglycine)(IC 50= 10 μM), was synthesized. The cyclization-cleavage of the protected precursor from the oxime resin significantly depended on the sequences of the linear tetrapeptides assembled by solid-phase-synthesis on the resin.
