Novel potassium channel activators: synthesis and structure-activity relationship studies of 3, 4-dihydro-2H-1, 4-benzoxazine derivatives.

Y MATSUMOTO, R TSUZUKI, A MATSUHISA…

Index: Matsumoto, Yuzo; Tsuzuki, Ryuji; Matsuhisa, Akira; Takayama, Kazuhisa; Yoden, Toru; Uchida, Wataru; Asano, Masaharu; Fujita, Shigeo; Yanagisawa, Isao; Fujikura, Takashi Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 103 - 114

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Citation Number: 46

Abstract

Strong potassium channel-activating effects were found among a series of novel 4- substituted 3, 4-dihydro-2H-1, 4-benzoxazine derivatives. The key step in preparation was the nucleophilic substitution of 3, 4-dihydro-2H-1, 4-benzoxazine (3) with activated halogenopyridines, such as halogenopyridine N-oxides (15a-c) and the borane adduct (15d) of 4-bromopyridine. Structure-activity relationship studies identified 2-(3, 4-dihydro-2 ...