Interaction of GTP Derivatives with ras-p2l Proteins tivity of the protein, and activate, in rod outer segments, the cyclicGMP phosphodiesterase that is the intracellular" targetw of the transducin-GTP complex. lS Therefore, we synthesized a series of N2-substituted GTPs, and, in this paper, describe the ability of these and other GTP derivatives to bind to ras-pel proteins.
