Optically Active Antifungal Azoles. XI. An Alternative Synthetic Route for 1-[(1R, 2R)-2-(2, 4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl) propyl]-3-[4-( …

…, H HOSONO, M YAMADA, M MIZUNO, K ITOH

Index: Ichikawa, Takashi; Kitazaki, Tomoyuki; Matsushita, Yoshihiro; Hosono, Hiroshi; Yamada, Masami; Mizuno, Masahiro; Itoh, Katsumi Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1947 - 1953

Full Text: HTML

Citation Number: 17

Abstract

New routes for the synthesis of the optically active antifungal triazoles 1-[(1R, 2R)-2-(2, 4- difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1, 2, 4-triazol-1-yl) propyl]-3-[4-(1H-1-tetrazolyl) phenyl]-2-imidazolidinone (1b) and the 3-[4-(1H-1, 2, 3-triazol-1-yl) phenyl]-2- imidazolidinone analog (1a) that possess an imidazolidine nucleus were established. The key synthetic intermediates,(2R, 3R)-3-(2, 2-diethoxyethyl) amino-2-(2, 4-difluorophenyl)-1 ...