Synlett

A convenient synthesis of 1-substituted 1, 2, 3-triazoles via CuI/Et3N catalyzed 'click chemistry'from azides and acetylene gas

LY Wu, YX Xie, ZS Chen, YN Niu, YM Liang

Index: Wu, Lu-Yong; Xie, Yong-Xin; Chen, Zi-Sheng; Niu, Yan-Ning; Liang, Yong-Min Synlett, 2009 , # 9 p. 1453 - 1456

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Citation Number: 35

Abstract

With the optimal conditions in hand, a variety of azides were explored in this 'click' process. Generally, as shown in Table [²] , the reactions were highly influenced by steric and electronic effects. Both electron-rich and electron-deficient aromatic azides, bearing substituents at meta- and para-position, afforded the product in excellent yields. It should be noted that the reaction of electron-rich azide (4-methoxy-phenyl azide) was slower than other 4-substitued ...