Structure-activity relationship within a series of pyrazolidinone antibacterial agents. 2. Effect of side-chain modification on in vitro activity and pharmacokinetic …

RJ Ternansky, SE Draheim, AJ Pike…

Index: Ternansky; Draheim; Pike; Counter; Eudaly; Kasher Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3224 - 3229

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Citation Number: 19

Abstract

The structure-activity relationship among a series of novel pyrazolidinone antibacterial agents is described. Specifically, the effect of modification of the side chain attached to the nitrogen at C-7 was explored in an attempt to improve the potency and spectrum of activity. This approach was successful in identifying several compounds having good in vitro profiles. These top candidates were then evaluated for their activity in uiuo, and their ...