e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Process Research for Multikilogram Production of Etamicastat: A Novel Dopamine β-Hydroxylase Inhibitor

A Beliaev, J Wahnon, D Russo

Index: Organic Process Research and Development, , vol. 16, # 4 p. 704 - 709

Full Text: HTML

Citation Number: 10

Abstract

... Pd complex, base, heating in organic solvent; d) CuI, DMEDA, base, heating in organic solvent. ... latter to the target ene-carbamate 22 was achieved according to the published procedure,(24) with ... of the acid 30 to 1 was achieved via a two-step Curtius process involving isolation ...

6,8-difluoro-2H-chromene-3-carboxamide Structure

6,8-difluoro-2H...

~73%

methyl N-(6,8-difluoro-2H-chromen-3-yl)carbamate Structure

methyl N-(6,8-d...

6,8-difluoro-2H-chromene-3-carbonitrile Structure

6,8-difluoro-2H...

~%

methyl N-(6,8-difluoro-2H-chromen-3-yl)carbamate Structure

methyl N-(6,8-d...

2,4-Difluorophenol Structure

2,4-Difluorophenol

~%

methyl N-(6,8-difluoro-2H-chromen-3-yl)carbamate Structure

methyl N-(6,8-d...

3,5-Difluoro-2-hydroxybenzaldehyde Structure

3,5-Difluoro-2-...

~%

methyl N-(6,8-difluoro-2H-chromen-3-yl)carbamate Structure

methyl N-(6,8-d...

6,8-difluoro-2H-chromene-3-carbonitrile Structure

6,8-difluoro-2H...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

6,8-difluoro-2H-chromene-3-carboxamide Structure

6,8-difluoro-2H...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

methyl N-(6,8-difluoro-2H-chromen-3-yl)carbamate Structure

methyl N-(6,8-d...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

(R)-methyl 6,8-difluorochroman-3-ylcarbamate Structure

(R)-methyl 6,8-...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

(R)-2-amino-3-(2,4-difluorophenoxy)propionic acid Structure

(R)-2-amino-3-(...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

Ethyl N-[(1S)-2-chloro-1-[(2,4-difluorophenoxy)methyl]-2-oxoethyl]carbamate Structure

Ethyl N-[(1S)-2...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

(S)-3-(2,4-difluorophenoxy)-2-((ethoxycarbonyl)amino)propanoic acid Structure

(S)-3-(2,4-difl...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

(S)-ethyl (6,8-difluoro-4-oxochroman-3-yl)carbamate Structure

(S)-ethyl (6,8-...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

(R)-(6,8-difluorochroman-3-yl)carbamic acid ethyl ester Structure

(R)-(6,8-difluo...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...

3,5-Difluoro-2-hydroxybenzaldehyde Structure

3,5-Difluoro-2-...

~%

2-Bromo-4,6-difluorophenol Structure

2-Bromo-4,6-dif...