Acetylenic carbamates. A new class of potential oncolytic agents

RD Dillard, G Poore, DR Cassady…

Index: Dillard,R.D. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 40 - 44

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Citation Number: 21

Abstract

One of the important features of portion€ 3 ivab tli: it R and R1 must both be aromatic groups for the carbamates to show significant antitumor effects. Conipounds that deviated from these requirements such as 1, 2, and 3 showed little if any effects. When R and R1 were both phenyl, compounds with varying degrees of potencies were obtained depending upon substituents on the remainder of the molecule. Although the effects of substituents on ...