Development of an improved process for doxercalciferol via a continuous photochemical reaction

BG Anderson, WE Bauta…

Index: Anderson, Bruce G.; Bauta, William E.; Cantrell, William R. Organic Process Research and Development, 2012 , vol. 16, # 5 p. 967 - 975

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Citation Number: 20

Abstract

Doxercalciferol (1α-hydroxyvitamin D2) is a commercially approved vitamin D derivative used to treat chronic kidney disease (CKD) patients whose kidneys cannot metabolically introduce a hydroxyl group at C1. A new process for the production of doxercalciferol from ergocalciferol was developed using a continuous photoisomerization of a known vitamin D intermediate as the key step, thus circumventing the limitations of batch ...